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  1. Effects Of E-Cigarettes On Allergic Airway Disease

    Effects Of E-Cigarettes On Allergic Airway Disease

    Effects Of E-Cigarettes On Allergic Airway Disease Flavored e-cigarettes are preferred by the majority of users yet their potential toxicity is unknown. Therefore our aim was to determine the effect of selected flavored e-cigarettes, with or without nicotine, on allergic airways disease in mice. To determine if any effects were due to nicotine, we compared the effects of flavored e-cigarettes with and without nicotine at 12mg/ML. Mice were exposed to indoor air and e-cigarette fumes twice a day for 30 minutes, six days a week. Effect of e-cigarette exposure on weight The effect of e-cigarette exposure on weight gain was assessed by measuring weight on Day 21 before the assessment of lung function. There was no effect of HDM on weight in female or male mice exposed to the e-cigarette with or without nicotine. male mice exposed to PG/VG with nicotine had reduced weight compared to Room Air exposed mice. Effect of e-cigarette exposure on HDM-induced airway inflammation e-cigarettes without nicotine macrophages were increased in HDM mice exposed Black Licorice compared to Room Air, with a trend towards increased total leukocytes. PG/VG, Kola or Banana Pudding did not alter total leukocytes, eosinophils or macrophages. there was no difference in neutrophils between HDM mice exposed to Room Air and those exposed to any of the nicotine-free e-cigarettes. This suggests that flavored e-cigarettes without nicotine have variable effects on airway inflammation during allergic airways disease, with the direction of the effect and the type of inflammatory cells affected dependent upon the specific flavor.  e-cigarettes with nicotine all e-cigarettes containing 12 mg/mL nicotine dampened airway inflammation. Compared to HDM mice exposed to Room Air, mice exposed to PG/VG and all flavored e-cigarettes had reduced total leukocytes, eosinophils, and macrophages. the present findings suggest that the effect of flavored e-cigarettes without nicotine on HDM-induced airway inflammation is dependent upon the specific flavor. In contrast, nicotine universally suppressed airway inflammation regardless of the flavor. Effect of e-cigarettes on HDM-induced airway hyperresponsiveness In mice exposed to e-cigarettes without nicotine or with nicotine, HDM treatment increased AHR as measured by Rrs, Ers, Rn, G, and H, There was no difference between HDM treated mice exposed to Room Air and any of the e-cigarette exposures as measured by Rrs, Ers, Rn. Effect of e-cigarette exposure on HDM-induced airway remodeling In mice exposed to nicotine-free e-cigarettes, HDM treatment increased soluble content. In mice exposed to 12 mg/mL nicotine, soluble lung collagen was increased with HDM treatment but there was no difference between mice exposed to Room Air and any of the e-cigarettes. Summary there was a consistent suppression of airway inflammation without any effect on AHR or airway remodeling due to e-cigarettes with nicotine, regardless of the flavor. Flavored e-cigarettes without nicotine had significant but heterogeneous effects on features of allergic airways disease. This suggests that some flavored e-cigarettes may alter asthma pathophysiology even when used without nicotine. Reference:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754426/  
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  2. We love testing | VLADDIN Slide Winners Announcement

    We love testing | VLADDIN Slide Winners Announcement

    We love testing | VLADDIN Slide Winners Announcement   Hi VLADDIN fans,   Thanks to everyone who has participated in our “We love testing” program, We’re totally blown away by the massive amount of interest in our giveaways. We’ve noticed you guys looking forward to the winning announcement. So we’ve decided to update winner lists in one thread, making it that much easier to track results. So here are the winners: They will make an honest review on VLADDIN Slide after receiving samples. I will collect all of their review on VLADDIN Blog, so you could know more details and real opinions from customers.
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    If you're tempted to buy and try your first vape, here is the most common mistake that beginning vapers make.   Buying a Poor Quality Vape or E-Cigarette. If you’re new to the world of electronic cigarettes, navigating with the different alternatives and arriving at the best product for you personally can seem to be as a mind-boggling procedure. You will find a wide variety of options accessible and new e-cigs are surfacing on the marketplace each week, so there is a lot of competition. Searching through reviews is the greatest method of choosing the right e-cigarette, but you’ll still have to know what you should keep an eye out to get the right one to your certain needs. The following tips will allow you to take into consideration what you’re searching for in an e-cigarette to make your selection.    1. Vapor Production The amount of vapor produced is really important if you’re trying to find a smoking cigarettes-like experience. Most brands will give a decent amount of vapor, although it is often notably less than a cigarette. This is another aspect that you develop more used to as time passes, but more vapor is always a good point. You’re also more likely to get a smoking-like “throat hit” if there is plenty of vapor in your electronic cigarette.   2. Nicotine Levels It’s also a smart idea to consider how much nicotine you’ll need. If you’re a huge tobacco user (greater than 20 daily) it might be a smart idea to look for a company that offers 24mg toner cartridges. This will make it more likely that this e-cig will satisfy your desires and you also won’t deplete the battery too quickly to have the nicotine success you’re trying to find. 18mg cartridges are enough for most users, though. If you’re seeking to reduce your smoking consumption, you should guarantee you can find at least four different alternatives. These are typically spread out apart by 6mg.   3. Batteries It is essential with regards to the battery is just how extended it is going to last. Generally, you’ll locate electric batteries that go on for between 200 and 300 puffs, with longer or heavier varieties providing the most utilization before needing charging you. Most starter packages arrive using more than one battery, therefore you can still keep an extra in case the one you’re utilizing expires. There are also two types of battery, automated and guide. For any smoke-like encounter (and minimal hassle), automatic battery packs are much better because they trigger whenever you suck in, producing vapor each time a cig would produce smoke cigarettes. Manual electric batteries are triggered with a button on the part. This may seem to be laborious, but you do get better control of the volume of vapor made.   4. Flavors Although it may look just like a superfluous, benefit part of the electronic cigarette, the wide range of tastes you get and their quality needs to be a significant thing to consider. The nicotine is the thing that you’re searching for, but you may also appreciate tastes including delicious chocolate, vanilla, even and gourmet coffee a lot more unusual types like pina colada. Cigarettes are usually well-represented, however, many variations from it are more accurate than the others. Much more flavor alternatives are good, but always consider to determine the top quality of them through testimonials. Even when you don’t think several tastes are very important to you personally, it’s safer to have choices since most “vapers” (customers of e-cigs) would rather move preferences frequently.  
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  4. Shipment Notice For The National Day In China

    Shipment Notice For The National Day In China

    Dear Customers,   The National Day in China is coming. To celebrate this once year grand holiday, Vladdin Team will have holiday from Oct 1st. 2019 to Oct 7th.2019. In the meanwhile shipment will be stopped from 30th Sep 2019 to 7th Oct 2019.  We feel sorry for the inconvenience we bring to you. If you have any question welcome contact your sales manager or email us via [email protected]   Best wishes  Vladdin Team
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  5. We love testing | VLADDIN Slide Call for Review

    We love testing | VLADDIN Slide Call for Review

     We love testing | VLADDIN Slide Call for Review Hey VLADDIN fans,   That’s right, VLADDIN Slide Pod Kit, is out now. It is available now at www.vladdinvapor.com .   To celebrate, we are giving 10 of fans the chance to test VLADDIN Slide, for FREE! But what is VLADDIN Slide? VLADDIN Slide Pod Kit is the first AIO pod system kit with a sliding panel in the world. The sliding feature allows for the convenient and fast filling option. There is no need to disassemble any parts of the device to refill. Simply slide the panel downwards and open the filling hole to refill. But that’s not all, It’s mesh coil not only provide great flavor but also the high vapor output. Due to the coil having a large contact area with wick, more vape juice can be vaporized. The Use of grid pattern coils provides the user’s with both richness and boldness of E-liquid. Another exciting feature is the adjustable bottom airflow. The airflow of the device is designed to allow each user to adjust it according to their preference. If you like large clouds, adjust to more restricted airflow, or a less restricted airflow for easy vaping. Whatever the preference may be, VLADDIN has you covered.   How to enter If you are ready and test VLADDIN Slide, click the link below to fill the application form. Link:https://www.vladdinvapor.com/base/demiware/ Ps: The more you write about yourself and the plan about the review, the more chance you will be chosen.   Rules: Sign up for a free account and complete the application. This event runs from October 1st to October 7th, 2019. The testers will be announced on the VLADDIN Blog on October 8th, 2019. 10 testers will be chosen. Open to residents of worldwide. Review Requirements: Once you have received your product, you need to post a link to your review on the community under review category within two weeks. If you haven’t provided a link after two weeks you will be unable to take part in the future testing activity. Where else to share your review: You could share your review on other website and social media (Facebook, Twitter, Instagram, etc.), YouTube, forums, blogs, deal websites, or other online spaces. If you’re sharing your review on social media, don’t forget to tag our official account(@vladdin_official) to increase the chances of being reposted. Once you have submitted your review, VLADDIN reserves the right to use, edit, and repost. VLADDIN reserves the right for the final explanation.  
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  6. Comparison:E-Cigarettes And Nicotine Replacement Therapy

    Comparison:E-Cigarettes And Nicotine Replacement Therapy

    The objective was to compare the efficacy of refillable e-cigarettes and nicotine replacement therapy NRT products, when accompanied by weekly behavioural support. The NRT arm n = 446 received NRT of their choice, provided for up to 12 weeks. The e-cigarette arm n = 438 received an e-cigarette starter pack and were encouraged to buy addtional e-liquids and e-cigarette products of their choice.  RESULTS  The 1-year quit rate was 9.9percent in the NRT arm and 18.0percent in the e-cigarette arm. The e-cigarette arm had significantly higher validated quit rates at all time points. Participants in the e-cigarette arm showed significantly better adherence and experienced fewer urges to smoke throughout the initial 4 weeks of their quit attempt than those in the NRT arm, and gave their allocated product more favourable ratings. Participants assigned to e-cigarettes reported significantly less coughing and phlegm at 1 year than those assigned to NRT. CONCLUSIONS Within the context of multisession treatment for smokers seeking help, e-cigarettes were significantly more effective than NRT, Can be considered as an aid to smoking cessation. The resources:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732716/
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  7. Reverse! Trump's latest statement: While I like the Vaping alternative to Cigarettes, we need to make sure this alternative is SAFE for all.

    Reverse! Trump's latest statement: While I like the Vaping alternative to Cigarettes, we need to make sure this alternative is SAFE for all.

    Reverse! Trump's latest statement: While I like the Vaping alternative to Cigarettes, we need to make sure this alternative is SAFE for all.   A reversal of e-cigarettes occurred on the evening of September 13, local time, US President Trump issued a tweet saying: “ While I like the Vaping alternative to Cigarette, we need to make sure this alternative is SAFE for ALL! Let’s get counterfeits off the market, an keep young children from Vaping! "   More than 12,800 people have left a message under this tweet, and 61,500 people like it. Some of them said: "I vape and help me stop cigarettes after 25years. I feel better and breath better" Another 63-year-old man said: "I’m 63 and quit smoking cigarettes 3 years ago (and started vaping.) I vape very low nicotine e-cigs. I feel great, my asthma is gone, lungs clear." Investor Michael Coudrey said. "While I agree with you Mr. President, I don't want you to hurt small-time business owners or vape distributors with over-regulating because maybe 6 people died when tobacco kills 600,000 per year."   At the White House petition online, a signing action “Stop Donald Trump from signing the federal flavor ban of e-cig products.” has also made a breakthrough. The action launched on September 11th local time, the number of signatures has exceeded 100,000. According to relevant regulations, the White House needs to make an official reply to the petition within 60 days.   Earlier, the US media reported that six people were suspected of dying from the lung problems caused by e-cigarettes, pushing the product to the forefront. The industry analysts believe that Trump's attitude towards the electronic cigarette industry has suddenly reversed, indicating that the US government has abandoned the individual and emotional factors and begin to consider the issue of its normative development from the overall situation of the industry.   After Trump’s first voice on e-cigarettes, global public opinion has been polarized. One party classify e-cigarettes and cigarettes into one category, and the other party indicates that the e-cigarettes with standard ingredients are much less harmful to people than traditional tobacco. They are good substitutes for tobacco. development of.   The authoritative media "Economist", which has a history of more than 170 years, said that “The facts have gone up in smoke, as so often happens during health scares. Although more research is needed, the evidence so far suggests that the recent vaping deaths in America did not come from products bought in a shop but from badly made items sold on the street. In five out of six cases, the tainted vaping products were bought illicitly; the other involved liquid bought in a legal cannabis shop in Oregon. One theory is that the vape fluid was mixed with vitamin E. This is an oil—something that should not enter the lungs. If inhaled, oil causes the type of symptoms that the stricken vapers display.”      There is a saying that the lung problems caused by e-cigarettes reported at present are mainly due to the fact that users personally add vitamin E in e-liquid. It is not related to E-cigarette. Studies have shown that inhalation of vitamin E can cause lung damage in the smoker. The US Food and Drug Administration (FDA) hopes that the public will eliminate the blind panic of e-cigarettes. They said that e-cigarette users should not buy e-liquid products containing cannabis extract, nor should they use inferior products. “When you buy an unlicensed liquid from an unregulated channel, you don’t know what you are going to face. That’s why the government does not encourage people to buy wine in informal channels because of these fake wine may be fatal. In Costa Rica, for example, 25 people have recently died of methanol. Like alcohol, regulators should also clearly distinguish between illegal e-cigarettes and those that are legal but not certified,” the Economist magazine said. The Economist concluded that it is more sensible to regulate e-cigarettes than to try to eliminate them. "Using e-cigarettes can be a dangerous habit, but it is far less lethal than traditional cigarettes.     Support for e-cigarettes is also the British Ministry of Public Health. Martin Dockrell, head of tobacco control at the UK Department of Public Health, said: “These people buy or DIY illicit liquids, mostly containing cannabis ingredients such as THC (tetrahydrocannabinol). These products come from the black market. Unlike the United States, all e-cigarette products in the UK are subject to strict quality and safety supervision by pharmaceutical and health care regulators. They encourage e-cigarette users to report any adverse reactions. The National Health Service said: "So far, there is no evidence proving that smoking e-cigarettes can cause harm to people around you. The available evidence shows that the risk of any hazard (e-cigarette) is extremely low, even with second-hand smoke. In comparison, for the future tobacco control work, the NHS and the UK Ministry of Public Health support the use of e-cigarettes instead of traditional cigarettes.   Last year, the British Ministry of Public Health recommended that hospitals should sell e-cigarettes and provide e-cigarette lounges for patients to encourage people to switch from traditional tobacco to e-cigarettes. So, what is the comparison between e-cigarettes and traditional cigarettes? The most authoritative report should come from the World Health Organization. In July of this year, WHO released the 2019 Global Tobacco Epidemic Report, which reads: Compared with traditional cigarettes, e-cigarettes produce less harm. If fixed smokers can completely replace cigarettes with well-regulated e-cigarettes, The toxic effects may be small, but not harmless.  
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  8. Catch us on VAPOUROUND BUS

    Catch us on VAPOUROUND BUS

    Hi, fam! VLADDIN cooperate with the  Vapouround holding a bus cruised in the UK. People in the UK if see the bus below, you could change a vladdin for free with your smoke tobacco. This activity aims to educate the public about vaping. Check the moment below:
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  9. Dependence Comparison: E-Cigarettes, Nicotine Gum And Tobacco Cigarettes

    Dependence Comparison: E-Cigarettes, Nicotine Gum And Tobacco Cigarettes

    Dependence comparison: e-cigarettes, nicotine gum and tobacco cigarettes   To assess dependence levels in users of e-cigarettes, and compare them with dependence levels in users of nicotine gums and tobacco cigarettes. Self-reports from cross-sectional Internet and mail surveys. Comparisons of: a. 766 daily users of nicotine-containing e-cigarettes with 30 daily users of nicotine-free e-cigarettes; b. 911 former smokers who used the e-cigarette daily with 451 former smokers who used the nicotine gum daily; c. 125 daily e-cigarette users who smoked daily with two samples of daily smokers who did not use e-cigarettes. Comparison of levels of dependence when vaping vs smoking In the 911 former smokers who used e-cigarettes daily, 74percentage rated their current dependence on e-cigarettes as “weaker” than their prior dependence on tobacco cigarettes, 21percentage as “same” and 3percentage as “stronger”. These 911 exclusive e-cigarette users reported that when they were smoking tobacco cigarettes, they smoked their first cigarette 23 minutes after waking, whereas they currently took their first puff on their e-cigarette 32 minutes after waking. Exclusive e-cigarette users rated their previous dependence on tobacco cigarettes at 90 on a scale of 0-100, whereas they rated their current dependence on e-cigarettes at 64. Among the 125 daily smokers daily dual users, 62percentage rated their current dependence on e-cigarettes as “weaker” than their current dependence on tobacco cigarettes, 28percentage as “same” and 3percentage as “stronger”. These dual users reported that they currently smoked 11.7 cigarettes per day, compared to 23.3 cigarettes per day before they started to use e-cigarettes. comparison of e-cigarette users dual users vs other smokers In daily smokers, vapers dual users rated their dependence on e-cigarettes lower 44.9 on a scale of 0 to 100 than smokers rated their dependence on tobacco cigarettes 68.6 to 84.5 on a scale of 0 to 100. comparison of users of e-cigarette vs nicotine gum In the subsample of short-term users of these products, there were few differences in dependence ratings between e-cigarette users and gum users. Results Dependence ratings were slightly higher in users of nicotine-containing e-cigarettes than in users of nicotine-free e-cigarettes. In former smokers, long-term users of e-cigarettes were less dependent on e-cigarettes than long-term users of the nicotine gum were dependent on the gum. Dependence on e-cigarettes was generally lower in dual users than dependence on tobacco cigarettes in the two other samples of daily smokers. Some e-cigarette users were dependent on nicotine-containing e-cigarettes, but these products were less addictive than tobacco cigarettes. E-cigarettes may be as or less addictive than nicotine gums, which themselves are not very addictive.    
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  10. Study The Dependence Of Smoking And Vaping On Nicotine

    Study The Dependence Of Smoking And Vaping On Nicotine

    Study the dependence of smoking and vaping on nicotine.   American Indian population has the highest percentage of smoking and EC use in the United States, focusing on the dual user subset, defined as people who smoked cigarettes and used ECs on some days or every day of the past 30 days. Study the dependence of cigarettes on dual users.   About two-thirds used a tanking product. Eleven percent used ECs without nicotine and another 9percentage were unsure of the nicotine content. A minority 40percentage enjoyed vaping more than smoking, and most 76percentage would smoke first on days they did both. Thirty-one percent vaped within 5 min of walking and another 24percentage within 30 min. Although the two-item heaviness of use index did not differ significantly between smoking and vaping, the ten-item Penn State Dependence Index PSDI suggested greater dependence on smoking than vaping 11.02 vs. 6.42, respectively; p less than .0001. The most common reasons for vaping were to reduce smoking 79percentage, enjoyment of flavors 78percentage, and the ability to vape where smoking is not allowed 73percentage. Perceptions of less harm to others 69percentage or to self were the next most common 65percentage. Fewer than half used ECs to reduce stress, for affordability, or because others used them. Individual measures show more dependence on smoking than vaping. The heaviness of vaping index and heaviness of smoking index did not differ significantly among the dual users p equal 0.22, but the mean PSDI dependence score for vaping was significantly lower than that for smoking 6.4−4.8 vs 11.0−5.0, respectively; p less than 0001. Results were unchanged when median values of the PSDI were compared via the Wilcoxon signed-rank test 6 vs 11, p less than.0001. The top three most commonly endorsed reasons for vaping were to cut down on smoking, liking EC flavors, and being able to vape in places wherein smoking is not allowed. Perceiving less harm to others or to oneself compared with smoking were the next most frequent responses. Less than one-half endorsed using EC to reduce stress, reduce cost, or because other persons important to them used EC. Other reasons write in for EC use were endorsed by only two 4.5percentage participants.   Results Nearly 20percentage of dual users used ECs either without nicotine or without knowing if the product containing nicotine. The PSDI indicated greater dependence on smoking than vaping. Reasons for vaping were nearly equal between smoking reduction and enjoying flavors.    References: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-7523-5#Fig1
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