The objective was to compare the efficacy of refillable e-cigarettes and nicotine replacement therapy NRT products, when accompanied by weekly behavioural support. The NRT arm n = 446 received NRT of their choice, provided for up to 12 weeks. The e-cigarette arm n = 438 received an e-cigarette starter pack and were encouraged to buy addtional e-liquids and e-cigarette products of their choice. 

RESULTS

 The 1-year quit rate was 9.9percent in the NRT arm and 18.0percent in the e-cigarette arm. The e-cigarette arm had significantly higher validated quit rates at all time points. Participants in the e-cigarette arm showed significantly better adherence and experienced fewer urges to smoke throughout the initial 4 weeks of their quit attempt than those in the NRT arm, and gave their allocated product more favourable ratings. Participants assigned to e-cigarettes reported significantly less coughing and phlegm at 1 year than those assigned to NRT.

CONCLUSIONS

Within the context of multisession treatment for smokers seeking help, e-cigarettes were significantly more effective than NRT, Can be considered as an aid to smoking cessation.

The resources：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732716/