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  1. Effects Of E-Cigarettes On Allergic Airway Disease

    Effects Of E-Cigarettes On Allergic Airway Disease

    Effects Of E-Cigarettes On Allergic Airway Disease Flavored e-cigarettes are preferred by the majority of users yet their potential toxicity is unknown. Therefore our aim was to determine the effect of selected flavored e-cigarettes, with or without nicotine, on allergic airways disease in mice. To determine if any effects were due to nicotine, we compared the effects of flavored e-cigarettes with and without nicotine at 12mg/ML. Mice were exposed to indoor air and e-cigarette fumes twice a day for 30 minutes, six days a week. Effect of e-cigarette exposure on weight The effect of e-cigarette exposure on weight gain was assessed by measuring weight on Day 21 before the assessment of lung function. There was no effect of HDM on weight in female or male mice exposed to the e-cigarette with or without nicotine. male mice exposed to PG/VG with nicotine had reduced weight compared to Room Air exposed mice. Effect of e-cigarette exposure on HDM-induced airway inflammation e-cigarettes without nicotine macrophages were increased in HDM mice exposed Black Licorice compared to Room Air, with a trend towards increased total leukocytes. PG/VG, Kola or Banana Pudding did not alter total leukocytes, eosinophils or macrophages. there was no difference in neutrophils between HDM mice exposed to Room Air and those exposed to any of the nicotine-free e-cigarettes. This suggests that flavored e-cigarettes without nicotine have variable effects on airway inflammation during allergic airways disease, with the direction of the effect and the type of inflammatory cells affected dependent upon the specific flavor.  e-cigarettes with nicotine all e-cigarettes containing 12 mg/mL nicotine dampened airway inflammation. Compared to HDM mice exposed to Room Air, mice exposed to PG/VG and all flavored e-cigarettes had reduced total leukocytes, eosinophils, and macrophages. the present findings suggest that the effect of flavored e-cigarettes without nicotine on HDM-induced airway inflammation is dependent upon the specific flavor. In contrast, nicotine universally suppressed airway inflammation regardless of the flavor. Effect of e-cigarettes on HDM-induced airway hyperresponsiveness In mice exposed to e-cigarettes without nicotine or with nicotine, HDM treatment increased AHR as measured by Rrs, Ers, Rn, G, and H, There was no difference between HDM treated mice exposed to Room Air and any of the e-cigarette exposures as measured by Rrs, Ers, Rn. Effect of e-cigarette exposure on HDM-induced airway remodeling In mice exposed to nicotine-free e-cigarettes, HDM treatment increased soluble content. In mice exposed to 12 mg/mL nicotine, soluble lung collagen was increased with HDM treatment but there was no difference between mice exposed to Room Air and any of the e-cigarettes. Summary there was a consistent suppression of airway inflammation without any effect on AHR or airway remodeling due to e-cigarettes with nicotine, regardless of the flavor. Flavored e-cigarettes without nicotine had significant but heterogeneous effects on features of allergic airways disease. This suggests that some flavored e-cigarettes may alter asthma pathophysiology even when used without nicotine. Reference:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754426/  
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  2. Shipment Notice For The National Day In China

    Shipment Notice For The National Day In China

    Dear Customers,   The National Day in China is coming. To celebrate this once year grand holiday, Vladdin Team will have holiday from Oct 1st. 2019 to Oct 7th.2019. In the meanwhile shipment will be stopped from 30th Sep 2019 to 7th Oct 2019.  We feel sorry for the inconvenience we bring to you. If you have any question welcome contact your sales manager or email us via [email protected]   Best wishes  Vladdin Team
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  3. Comparison:E-Cigarettes And Nicotine Replacement Therapy

    Comparison:E-Cigarettes And Nicotine Replacement Therapy

    The objective was to compare the efficacy of refillable e-cigarettes and nicotine replacement therapy NRT products, when accompanied by weekly behavioural support. The NRT arm n = 446 received NRT of their choice, provided for up to 12 weeks. The e-cigarette arm n = 438 received an e-cigarette starter pack and were encouraged to buy addtional e-liquids and e-cigarette products of their choice.  RESULTS  The 1-year quit rate was 9.9percent in the NRT arm and 18.0percent in the e-cigarette arm. The e-cigarette arm had significantly higher validated quit rates at all time points. Participants in the e-cigarette arm showed significantly better adherence and experienced fewer urges to smoke throughout the initial 4 weeks of their quit attempt than those in the NRT arm, and gave their allocated product more favourable ratings. Participants assigned to e-cigarettes reported significantly less coughing and phlegm at 1 year than those assigned to NRT. CONCLUSIONS Within the context of multisession treatment for smokers seeking help, e-cigarettes were significantly more effective than NRT, Can be considered as an aid to smoking cessation. The resources:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732716/
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  4. Dependence Comparison: E-Cigarettes, Nicotine Gum And Tobacco Cigarettes

    Dependence Comparison: E-Cigarettes, Nicotine Gum And Tobacco Cigarettes

    Dependence comparison: e-cigarettes, nicotine gum and tobacco cigarettes   To assess dependence levels in users of e-cigarettes, and compare them with dependence levels in users of nicotine gums and tobacco cigarettes. Self-reports from cross-sectional Internet and mail surveys. Comparisons of: a. 766 daily users of nicotine-containing e-cigarettes with 30 daily users of nicotine-free e-cigarettes; b. 911 former smokers who used the e-cigarette daily with 451 former smokers who used the nicotine gum daily; c. 125 daily e-cigarette users who smoked daily with two samples of daily smokers who did not use e-cigarettes. Comparison of levels of dependence when vaping vs smoking In the 911 former smokers who used e-cigarettes daily, 74percentage rated their current dependence on e-cigarettes as “weaker” than their prior dependence on tobacco cigarettes, 21percentage as “same” and 3percentage as “stronger”. These 911 exclusive e-cigarette users reported that when they were smoking tobacco cigarettes, they smoked their first cigarette 23 minutes after waking, whereas they currently took their first puff on their e-cigarette 32 minutes after waking. Exclusive e-cigarette users rated their previous dependence on tobacco cigarettes at 90 on a scale of 0-100, whereas they rated their current dependence on e-cigarettes at 64. Among the 125 daily smokers daily dual users, 62percentage rated their current dependence on e-cigarettes as “weaker” than their current dependence on tobacco cigarettes, 28percentage as “same” and 3percentage as “stronger”. These dual users reported that they currently smoked 11.7 cigarettes per day, compared to 23.3 cigarettes per day before they started to use e-cigarettes. comparison of e-cigarette users dual users vs other smokers In daily smokers, vapers dual users rated their dependence on e-cigarettes lower 44.9 on a scale of 0 to 100 than smokers rated their dependence on tobacco cigarettes 68.6 to 84.5 on a scale of 0 to 100. comparison of users of e-cigarette vs nicotine gum In the subsample of short-term users of these products, there were few differences in dependence ratings between e-cigarette users and gum users. Results Dependence ratings were slightly higher in users of nicotine-containing e-cigarettes than in users of nicotine-free e-cigarettes. In former smokers, long-term users of e-cigarettes were less dependent on e-cigarettes than long-term users of the nicotine gum were dependent on the gum. Dependence on e-cigarettes was generally lower in dual users than dependence on tobacco cigarettes in the two other samples of daily smokers. Some e-cigarette users were dependent on nicotine-containing e-cigarettes, but these products were less addictive than tobacco cigarettes. E-cigarettes may be as or less addictive than nicotine gums, which themselves are not very addictive.    
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  5. Study The Dependence Of Smoking And Vaping On Nicotine

    Study The Dependence Of Smoking And Vaping On Nicotine

    Study the dependence of smoking and vaping on nicotine.   American Indian population has the highest percentage of smoking and EC use in the United States, focusing on the dual user subset, defined as people who smoked cigarettes and used ECs on some days or every day of the past 30 days. Study the dependence of cigarettes on dual users.   About two-thirds used a tanking product. Eleven percent used ECs without nicotine and another 9percentage were unsure of the nicotine content. A minority 40percentage enjoyed vaping more than smoking, and most 76percentage would smoke first on days they did both. Thirty-one percent vaped within 5 min of walking and another 24percentage within 30 min. Although the two-item heaviness of use index did not differ significantly between smoking and vaping, the ten-item Penn State Dependence Index PSDI suggested greater dependence on smoking than vaping 11.02 vs. 6.42, respectively; p less than .0001. The most common reasons for vaping were to reduce smoking 79percentage, enjoyment of flavors 78percentage, and the ability to vape where smoking is not allowed 73percentage. Perceptions of less harm to others 69percentage or to self were the next most common 65percentage. Fewer than half used ECs to reduce stress, for affordability, or because others used them. Individual measures show more dependence on smoking than vaping. The heaviness of vaping index and heaviness of smoking index did not differ significantly among the dual users p equal 0.22, but the mean PSDI dependence score for vaping was significantly lower than that for smoking 6.4−4.8 vs 11.0−5.0, respectively; p less than 0001. Results were unchanged when median values of the PSDI were compared via the Wilcoxon signed-rank test 6 vs 11, p less than.0001. The top three most commonly endorsed reasons for vaping were to cut down on smoking, liking EC flavors, and being able to vape in places wherein smoking is not allowed. Perceiving less harm to others or to oneself compared with smoking were the next most frequent responses. Less than one-half endorsed using EC to reduce stress, reduce cost, or because other persons important to them used EC. Other reasons write in for EC use were endorsed by only two 4.5percentage participants.   Results Nearly 20percentage of dual users used ECs either without nicotine or without knowing if the product containing nicotine. The PSDI indicated greater dependence on smoking than vaping. Reasons for vaping were nearly equal between smoking reduction and enjoying flavors.    References: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-7523-5#Fig1
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  6. How to store e-juices? A better way to keep fresh flavor

    How to store e-juices? A better way to keep fresh flavor

    How to store e-juices? A better way to keep fresh flavor   1.   Need Sealed storage   Vegetable glycerin and propylene glycol are both hygroscopic liquid additives, which are easy to absorb water in the air. Therefore, it is better to seal the unsealed smoke oil strictly, such as using plastic wrap to avoid contact with moist air and spoilage. What is PG/VG?   2.   Stay away from light   Additives and extracts such as essence and nicotine are also easy to react under high temperature and strong light. Because light and air oxidize the nicotine present in the e-juice, changing its color. When nicotine oxidizes, it produces cotinine. Ultraviolet light provides the energy needed to further catalyze the oxidation process and promote the production of cotinine. The more the liquid oxidizes, the less nicotine it contains. Impairs the taste and degrades the liquid more quickly. You can't completely avoid oxidation, because even if you fill the edges, some of the oxygen gets trapped in the electron fluid. However, you can minimize the impact of the process by staying out of the light. Therefore, it is highly recommended to store the e-juice away from the light and keep it closed, and use it as soon as possible.   3.   Keep away from heat   As the liquid heats up, the molecules gain more energy and begin to interact with other molecules. They may also be further decomposed into smaller elements. Therefore, if the e-juice is exposed to a lot of heat, the flavor composition of the liquid will change, which will change the taste of the e-juice. So we should pay attention to low-temperature storage, try not to put in more than 50 degrees of environmental temperature, avoid direct smoke light and humid environment. For example, if stored in the refrigerator, it can extend the shelf life of the t-juice to some extent, and maintain the original flavor of the e-juice.   4.   Stored in colored glass bottles   Because plastic can react with e-juice during any chemical reaction caused by heat or air, changing its taste depending on the choice of e-juice. On the other hand, glass reduces the chance of any interaction and keeps contact with air to a minimum. Colored bottles keep light away from them more efficiently than transparent ones, so colored glass bottles are an effective way to store them.   5. Date marked   Mark the purchase date and expiration date of the e-juice when you store it and make sure you know the warranty date. Because many people like the taste of fresh, they buy a variety of flavors before they use them. When stored, it is easy to forget the expiry date of the liquid itself if no time is noted. By marking the date, you don't have to worry about the expired and deteriorated e-juice when using it.   6.   Keep away from children and pets   Store them out of reach of children and pets. Place them on high shelves or cabinets so they are not easily touched. Electronic liquids contain nicotine salts, which can be toxic if eaten directly.   7. Check   When stored for a period of time, it is possible that the e-liquid changes due to improper methods. How to determine whether the e-liquid is fresh after being stored for a period of time? During the shelf life, the best way is to smell. Turn on the liquid. If it smells the same, keep using it. If it smells bad, throw it away. Second, look at the color. If the color of the liquid changes, it has oxidized and needs to be thrown away. Finally, see if there is any impurity formation. If there are black and other unknown particles in the electronics industry, please immediately throw them away.   By following these simple steps, you can keep your e-juice fresher and ensure you enjoy your experience every time you arrive at the stored electronic juice bottle.  
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  7. what is the pod system? This is something you need to know

    what is the pod system? This is something you need to know

    what is the pod system? This is something you need to know   What is the pod system? The Pod system is divided into two components: a Pod with a heating core and e-liquid juice, and a portable battery with a certain power. Although the battery is small, it has a capacity of more than 180mAh. And keep up with your day’s need. It has power buttons, but usually, they're automatic, which means you just breathe in and they generate steam.   Two types of pod system Refillable pod system: gives you more freedom in flavor. These devices are also known as open systems. It allows users to manually fill the cartridge and use any flavor they want. Pre-filled pod system: also known as a closed system, non-refillable pod vapes use pre-filled e-liquid boxes. The main advantages are the complexity of not selecting the right e-liquids and the convenience of not having to fill them yourself.   How does the pod system work? Make sure the battery is fully charged. Make sure the pod contains enough e-liquid. Allow the e-juice to settle for at least 5-10 minutes until fully absorbed into the wick. Insert the pod firmly into the device. If the pod system is activated, continue vaping as if it were a regular cigarette. In order to get the longest life from your pod system, do not use it when they are empty or you may run the risk of burning coils. Once the e-liquid is almost gone, it needs to be refilled or processed. The battery life of the Pod system depends on how you use it. If you use it multiple times a day, your battery will likely run out faster and you'll probably need to recharge it often. How To Refill?   Nicotine salts? Nic salts and pod systems work well together. Electronic juices containing these salts work better from mouth to lung (MTL), and the pod model allows MTL to atomize. E-liquids with high nicotine free base content can cause severe sore throats. When nicotine salts are highly concentrated in the e-liquid, they provide a smoother and more satisfying throat. Nicotine salt works well in low-power units, so it is ideal for use in pod systems.   The Benefits of the pod system? Simple and easy to use The pod comes with its own heating core and cannot be replaced. When there is no electronic liquid, you just need to inject a new e-liquid or replace a new pod to continue to use, which requires no complicated operation and maintenance and is very simple and easy to use. Easy to carry Shaped like a pen or badge, the Pod system is a small, lightweight, ultra-portable e-cigarette. Smoking Alternative Because it's used with e-liquids, which contain nicotine salts, PG, VG, and flavoring. The nicotine salt content in e-cigarettes can meet the needs of smokers for nicotine, and there are no harmful substances generated during the burning of cigarettes, which can reduce the harm to the body caused by cigarettes, at the same time, it can also stimulate the throat feeling of cigarettes, making it a good substitute for cigarettes. You can change the flavor you can change the flavor what you want at any time. Because the pod's capacity is relatively small, it can change the e-liquid at any time to meet your own preferences. At the same time, the manufacturer also has a prefilled pod for various flavors. So you can use different pods to change the flavor.   Disadvantages of the pod system Small battery capacity Due to its small size, the pod system has less battery capacity than the box mod. Battery life is relatively weak, and for this reason, the voltage of the pod system is generally not adjustable. Limited steam production The Pod system produces about the same amount of smoke as a cigarette, but much less than a Pod mod. Limited flavor selection Because each pod system has a different design and shape. This also means that smokers are limited by the flavor offered by manufacturers. But now a number of vendors are starting to set up populatable pods, which is definitely a good thing for consumers. The price is more expensive Frequent changes to the Pod are needed for better flavor restoration. This also increases the cost of buying, which is higher.   How to choose a pod system You should consider the following factors: Size and shape: the portable pod system is smaller in size, but it comes in different shapes. Everything from pens to badges. Depending on the shape you choose, the pod system gives you a different feel as you move or use it. Pod capacity: due to its small size, pod capacity is also relatively small. However, pod systems of different brands also have different capacities. The lower the capacity, the more often you need to replace or refill the container. So consider the pod's capacity. Pod selection: if you choose pre-filled pods, you cannot fill your own electronic liquid. Because most devices only accept their brand of electronic liquids. You can also choose a fillable pod so you can reuse it to fill your favorite flavor.   Who should use pod system? Smokers who want to quit; Pod system can also replace cigarettes for daily use. The Beginner’s Guide to VLADDIN pod system.  
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  8. Vape Israel Expo – Come And Try Our New Launch Products

    Vape Israel Expo – Come And Try Our New Launch Products

    Vape Israel Expo – Come and Try Our New Launch Products   From June 27th to 28th, the first international vape exhibition -- Vape Israel Expo will be held at Expo Tel Aviv, for 2 days. For the first time ever in Israel, all of the worlds biggest vape brands will be showcasing their products under one roof. Make sure you don't miss out on the opportunity to come and test the latest technologies and taste the newest liquids! We are glad to inform all of our fans or vape lovers, VLADDIN team will attend the expo at the booth: E11. We will bring the newest products VLADDIN Eden Kit, VLADDIN Slide Kit to the expo. Please stand by our booth and say hi to us, you might get the lovely stuff like hat, t-shirt, leather case freely! Meanwhile, as one of the exhibitor, we are glad to meet all partners who is interested in working with us or sharing industry information. If you have any question, or , if need any help, please contact us via email: [email protected] or directly comment below ↓.  And the official website of Vape Israel Expo: https://vapeisrael.com  More information about the exhibition of vladdin:https://www.vladdinvapor.com/base/eventlist
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  9. 58 Successful Smoke-quitting Stories You Ought to Know

    58 Successful Smoke-quitting Stories You Ought to Know

    58 Successful Smoke-quitting Stories You Ought to Know   Smoke is an unhealthy life hobbit. You may get lots of tips or solution way to help quit smoking. On Quora, the biggest Q&A platform, the most closely watched questions are: What are some successful ways to quit smoking? And, how can I motivate myself to quit smoking? Therefore, as the coming of No Tobacco Day, we hold an activity encourage people to share their smoke-quitting experience to inspire those who still at sea. Activity hold successfully, so here is the all comment below we would like to share with you:   @nkwoel: I was a heavy smoker three years ago. Been smoke for 20 years. When I did some exercises, my lung often felt burnt and cause cough. Sometimes hard to inhale fresh air. But, after a change into vaping, hurt is getting gone. And now I can do exercises easily without feeling burnt and hurt.  A Heavy Smoker Think Of E Cigarette   @ dope_sachin: i have just burned my throat by smoking cigarette and cough all day.. along. It was so painful to quit without any help but then a miracle happens with me is i won a vape kit in a giveaway and that it was a juul and that Juul totally changed my point of view to quitting smoke... today i vape 0mg no nicotine and I love that......    @ venusvapes: I started vaping when I got sick & could not breathe anymore. I was smoking 2 packs a day & i was diagnosed w/cancer. It truly has saved my life    @ gobills77: I started smoking when j was about 14 and then one day about 8 years later I quit cold turkey for about 8 years. Then one day I started again, the worst movie I've ever made... Well, I just recently bought a vape mod after trying patches and gum and inhalers.... and I haven't had a cigarette in a month. I can breathe better now. Vaping saved my life, and my wallet lol. I'd love to win one of these pods for a friend of mine who needs to quit.   @ marthinha_borges: I smoked 35 years. Last year I got sick and went to the doctor, after having an x-ray of the lung, He told me that I was having emphysema. I was disturbed by that is after about 4 months I decided to pick up the electronic cigarette. I stopped smoking on the same day. It was the best thing I did in my life, in the first 15 days I eliminated a lot of secretion from my body and my breathing has returned to normal. I have not smoked in 2 months, I'm feeling very happy, without unpleasant smells. The pod system (electronic cigarette) is life! Well worth it, I advise everyone to start using it right now.   @ aryonugrahaa: I have just burned my throat by smoking cigarette and cough all day along. it was so painful to quit without any help but then a miracle happens with me is I won a vape kit in a giveaway and that it was a juul and that juul totally changed my point of view to quit smoke. today i vape 0mg no nicotine and i love that   @ tina77vapes: I was told if I kept smoking I’d lose both my legs!! Two years ago I was facing double amputation, today I am still walking thanks to vaping.   @ black_vape54: have a history of shortness of breath and I still smoke. 2 years ago I knew vape and since I vape my illness never relapsed. since then I quit smoking and switched to vaping. I hope I can win this. because I really need this one #vladdinkit. thanks for this opportunity   @ ca_na_ra: I have quit smoking since 3 years ago, the first reason and inspiration for me to quit smoking was because of the birth of my child in 2016 and since the birth of my first child I started stopping tobacco cigarettes and started trying to switch to using vape until now I was right stop right from cigarettes ❤❤ what about your experience    @ ferdianajr_: I stop smoking since 2018, because one day i saw a video tricking on Instagram, and its look cool, and i try to buy my device for the first time, I try to make some trick and i enjoy and very happy can make some trick with vapor, since that day i already quit smoking until now, vaping change my life and my lifestyle :)    @ ahin_djong_945: My dad, was a heavy smoker. When i was a child, maybe 10 years old. I saw my father cigarettes stock. He's can smoke more 2box/pack for one day. I'm learning to smoke from my dad. Years by years and the disaster has begun. my father got a stroke, and his lungs were already weak. after recovery, my father had totally stopped smoking but not to me. I became a heavy smoker. a day I can spend two packs of cigarettes too. Until i was 29 years old. I'm still smoking. When I saw an advertisement of someone using a vape, and I was interested to use vape too. Start to find out the advantages of vape and all kind of vape types. @rockinthevape: , i smoked for 42 years, then two of my sons started playing around with vaping and I slowly started buying stuff and found what I? Like. That was in 2016. today I am smoke-free.   @vape_the_magic_dragon: I smoked for a few years and when i heard the new trend of vaping i decided to try it out. Now 5 years later I'm still vaping. Smoking is dead vaping is the future and the future is now.    @ m_perdi: First I found out what factors made me want to stop smoking. I thought it myself, what is the strong reason that makes me stop? Apparently, I found two things: Health and money.   @ leebochog: Looked for an alternative to smoking, I and my friends started vaping and since then no more cigarettes and we all quit smoking.  @ echathebekz: I've been quit smoking since 2015. Before I know vladdin re, I've searched the most tasteful pods with refillable Cambridge, so I choose vladdin re as my daily pods... before i use vladdin, I used to use the regular electrical mod and mechanical mod. Thanks vladdin for having me to share a bit my stop quitting experience..!!    @ kblock1953: I completely stopped smoking since the 23.06.2018, the way was very difficult. But now I could not imagine it without my VAPE ... if MTL / DL, just ingenious this invention @ avnan_0108: This is very amazing, where I strongly support the existence of "WORLD NO TOBACCO DAY". These movements are very good, because they can reduce tobacco cigarette users to immediately move to the healthier ones, vape. about 4 years ago, I was a slave to tobacco cigarettes. every day, every hour even every time I am always called tobacco cigarettes, and I am a slave to tobacco cigarettes. Every day I can run out of 2 to 3 packs of cigarettes, because every activity I do is definitely a friend's cigarette (except bathing) if you calculate the amount of money I spend on cigarettes per day. And one day I saw someone who was smoking but not tobacco cigarettes and the smoke that was produced was far more extraordinary WOW Amazed me
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  10. What are the effects of e-cigarettes on cardiovascular function?

    What are the effects of e-cigarettes on cardiovascular function?

      What are the effects of e-cigarettes on cardiovascular function?   There are  estimated 1.3 billion smokers worldwidely, and the incidence of smoking-related diseases and cancer deaths is increasing every year. A variety of smoking cessation drugs, including nicotine replacement therapy, wellbutrin and vanilicin, as well as behavioral support, have been developed by various institutions to be the most effective way to quit smoking. However, even with the best methods, the relapse rate within six months is about 75 per cent. E-cigarettes use batteries to electrically heat a solution containing propylene glycol or glycerin, water, flavouring agents and nicotine as an alternative to conventional cigarettes. E-cigarettes have become the most popular smoking cessation aid in England, but information about their impact on cardiovascular function is limited. What are the effects of e-cigarettes on cardiovascular function?   e-cigarette have become the most popular smoking cessation aid in England, And there is evidence that they are effective as AIDS to smoking cessation. However, data on their effects on cardiovascular function are limited and there is a lack of consensus on their potential effects in the smoking cessation community: consequently, further research has been requested by the European Parliament, the British Medical Association, regulatory agencies, clinicians and researchers Lancet; BMC Public Health; As e-cigarettes are not solely nicotine-based products, existing research exploring the effects of nicotine on the cardio-vasculature.   Methods   This is a practical, 3-group, randomized, evaluator blind, single-center trial to explore the cardiovascular physiological effects of using e-cigarettes nicotine-free and nicotine-free, assessed separately, combined with behavioral support as a smoking cessation method compared with a combination of NRT and behavioral support.The primary outcome will be macro-vascular function, determined by a Flow Mediated Dilatation ultrasound assessment, 6 months following participants’ “quit date”. Conclusion   Participants will be assessed at baseline, 3 days following their self-determined “quit date”, at intervention end 3 months and 6 months following their “quite date”. Findings are expected to give an indication of the cardiovascular effects of e-cigarettes both in the short- and in the medium-term period, informing the general public, policy holders and researchers, helping to define the future role of e-cigarettes as a smoking cessation aid.  The resources:Smokers making a quit attempt using e-cigarettes with or without nicotine or prescription nicotine replacement therapy: Impact on cardiovascular function (ISME-NRT) - a study protocol  
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